HMGB1 and neoplasm: Among the HDP, some have been reported as ICD inducers, such as LTX-315 which, in addition to its effect in reducing pro-tumour immune cells, has also been reported to induce the emission of DAMPs (calreticulin, HMGB1 and ATP) and to induce in vivo myeloid and T lymphocyte tumour infiltration (195).