showed that a cocktail of pro-inflammatory cytokines including TNF-α, IFN-γ, IL-1α, IL-1β, IL-18, IL-6, IL-8, and IL-15 induced cell death in NCI-60 colon cancer cells, while individual treatments or a cocktail lacking TNF-α and IFN-γ did not induce cell death, suggesting a synergistic effect of this cytokines signalling to induce cell death. The gene discussed is IFNG; the disease is malignant colon neoplasm.