Simultaneous blockade of TIGIT and PD-L1 has elicited tumor rejection and antigen-specific protection in CT-26 tumor-bearing mice (43), and TIM-3 has been implicated in inhibiting the cytotoxic function of Vδ2 T cells by suppressing the release of granzyme B and perforin (44). This evidence concerns the gene PRF1 and neoplasm.