Taken together, Vδ2 T cells can induce pyroptosis in mesothelioma cells via the canonical pathway but only induce active IL-18 and IL-1β in MSTO-luc but not H2052-luc cells, which may suggest the higher resistance of H2052-luc cells towards Vδ2 T cell killing. Here, IL18 is linked to mesothelioma.