And many malignant B-cell lymphomas of post-GC origin, such as DLBCL-ABC, MZL, disseminate to extranodal organs/tissues, such as CNS, gastrointestinal tract, urogenital system, mucosa, skin, etc. In line with this, in Eμ-Myc;UtxKO mouse models with high incidence of extranodal lymphoma, most of the lymphoma also originate from mature B-cell stage. This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.