Taken together, overexpression of Myc drives the pre-malignant B-cell progenitor initially to benign B-cell hyperplasia, and a transformed clone, for example driven by loss of UTX, then make the benign B-cell hyperplasia into nodal lymphoma and/or further spread to extranodal sites to form extranodal lymphoma. This evidence concerns the gene KDM6A and lymphoma.