Although Eμ-Myc transgenic mouse is initially designed to resemble Myc translocation observed in human Burkitt Lymphoma (BL) (6), lymphomas arising in Eμ-Myc mice exhibit significant inter-tumor heterogeneity and both BL-like and DLBCL-like gene expression patterns are observed (7–9). This evidence concerns the gene MYC and diffuse large B-cell lymphoma.