IFNG and neoplasm: They can increase the amount of IFN-γ secreted by αβ T to regulate the TME by inducing recruitment of CTL, NK cells, and Th1, inducing M1-type polarization of macrophages (12), activating dendritic cells to induce their maturation (88), upregulating the expression of MHC class I in tumor cells to improve anti-tumor immune response (89) and preventing pro-tumor T helper cells from functioning (Treg, Th17 and/or Th2).