For example, IL-18 can enhance NK cells ability to kill colorectal cancer cells via the miR-574-3p/TGF-β1 axis (68) and has been proven to enhance therapeutic effects of immune checkpoint inhibitors (ICIs) against cancer cells in animal models through accumulation of pre-mNK cells, memory-type CD8(+) T cells, and suppression of Tregs (69). The gene discussed is CD8A; the disease is cancer.