They were applying a comprehensive image analysis of digital image whole slides.; they revealed that the high mean density of combined CD8+, FOXP3+, and PD-1+ TILs in tumor epithelium (in tumor nest contact with tumor cells; distance < 20μm) and stroma (in tumor stroma not contact with tumor cells; distance > 20μm) of biopsies was associated with the better histopathological response (tumor regression grade) in 188 post‐nCRT resected specimens, and only CD8+ was associated with outcome (78). This evidence concerns the gene CD8A and neoplasm.