Cellular communication network factor 2 (CCN2) is a component of the SASP that induces senescence in cultured tubular cells, is involved in experimental renal fibrosis following IRI- and FA-AKI and can activate the RIKP3/NLRP3 pathway in the acute phase of FA-AKI (93–95). This evidence concerns the gene CCN2 and Friedreich ataxia.