This assay now enables complementary analysis of total tenascin-C alongside splicing-targeted assays which pave the way for correlation of tenascin-C and specific isoforms with markers of inflammation, such as CRP or fibrinogen, and clinical data, for example, in RA including DAS28 score, tissue erosion, disease duration, treatment response, and cellular or molecular endotypes. The gene discussed is CRP; the disease is rheumatoid arthritis.