In addition to the central role of IL-36 receptor signaling in the pathogenesis of GPP, evidence suggests that IL-36 may have a role in the pathogenesis of other diseases (115, 116); including inflammatory bowel disease (117, 118), hidradenitis suppurativa (119, 120), arthritis (121–123), systemic lupus erythematosus (124, 125), pyoderma gangrenosum (126), and Netherton syndrome (127). Here, IL1RL2 is linked to arthritic joint disease.