In addition to the central role of IL-36 receptor signaling in the pathogenesis of GPP, evidence suggests that IL-36 may have a role in the pathogenesis of other diseases (115, 116); including inflammatory bowel disease (117, 118), hidradenitis suppurativa (119, 120), arthritis (121–123), systemic lupus erythematosus (124, 125), pyoderma gangrenosum (126), and Netherton syndrome (127). The gene discussed is IL1RL2; the disease is systemic lupus erythematosus.