As TRIM20 mutations are associated with familial Mediterranean fever (170), and as TRIM20 interacts with both ASC and NLRP3 (66) and links those to the autophagy machinery (32), it is tempting to speculate that TRIM20 recognises assembled inflammasome complexes to target them for autophagy in order to simultaneously remove the (perceived) threat and the danger signal. The gene discussed is NLRP3; the disease is familial Mediterranean fever.