SOAT1 and leishmaniasis: In the Gln and 11S comparison group, up-regulated proteins showed significant enrichment in pathways associated with immune system- and human disease, such as Th1 and Th2 cell differentiation (ko04658), platelet activation (04611), JAK-STAT signaling pathway (ko04630), Th17 cell differentiation (ko04659), primary immunodeficiency (ko05340), inflammatory bowel disease (IBD, ko05321), and leishmaniasis (ko05140; P < 0.05, Figure 6A).