The accumulation of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the neuronal cell membrane in the AD mouse brain (263) suggests that PC and PE may transduce signals via TREM2-NFAT (261, 264), potentially enhancing TREM2 activity and promoting a protective phenotype in microglia. This evidence concerns the gene TREM2 and Alzheimer disease.