Using a lipopolysaccharide (LPS)-induced model of AD neuroinflammation, Sun and coworkers (325) demonstrated that SOCE-mediated activation of the PLC/CaN/NFAT pathway up-regulated NADPH oxidase and NOD-like receptor family protein 1 (NLRP1) inflammasome, both playing a pivotal role in oxidative stress and neuronal inflammation. This evidence concerns the gene NUP214 and Alzheimer disease.