APP and Alzheimer disease: Using the senescence-accelerated mouse prone 8 (SAMP8) model, which is considered a late-onset AD mouse model characterized by tau hyperphosphorylation and altered APP processing (278), Vassilopoulos and colleagues demonstrated that a newly synthesized I2-IRs ligand, named B06, reduced the expression of pro-inflammatory cytokines by inhibiting CaN/NFATc1 signaling (274).