In nervous tissue, abnormalities in CaN/NFAT signaling are increasingly related to a variety of pathological features associated with Alzheimer’s disease (AD), including synaptic dysfunction, glial activation, and cell death (11) The prevalence of studies, as will be discussed in subsequent sections, indicates a causative relationship between NFAT and AD, and some of the first evidence has been provided by Abdul and colleagues who demonstrated a relationship between amyloid toxicity and NFAT signaling (10). This evidence concerns the gene NUP214 and Alzheimer disease.