In the Drosophila AD model, overexpression of human amyloid precursor protein (APP) induced synaptic hyperexcitability and concurrent upregulation of Ca2+-related signaling genes, including Dmca1D (L-type Ca2+ channel), CaN, and the inositol 1,4,5-triphosphate receptor (IP3R) (309). Here, NUP214 is linked to Alzheimer disease.