ISG15 and infection: In the last publication the authors report 14 highly preserved IFN-I related genes that are directly linked to different host response profiles, namely: BST2, IFIT1/2/3, IFITM1, ISG15, MX1/2, OAS1/2/3/L, RSAD2, and STAT1, with all of them to belong in the union of genes that compose the two-stage SCOV2 molecular fingerprints found by our experiments as down-regulated during the early stage of the infection (section 3.1.1).