These changes partially reflected the modifications in liver T-cell distributions as CD8+ T-cell prevalence increased by about 5 folds in mice with MASH (10.2 ± 2.4% vs 1.7 ± 1.2%; p<0.03), without appreciable changes (4.3 ± 1.9% vs 4.1 ± 1.4%) in the fraction of CD4+ T cells. This evidence concerns the gene CD8A and metabolic dysfunction-associated steatohepatitis.