As observed in MCD-fed mice, MASH improvement in ICOSL-deficient mice receiving WD was characterized by a significant lowering in the liver fraction of CD11bhigh/F4-80+ MoMFs which contains a high proportion of cells expressing the monocyte marker lymphocyte antigen 6 (Ly6Chigh) (Figure 5A). This evidence concerns the gene LY6S and Wilson disease.