TREM2 and metabolic dysfunction-associated steatohepatitis: However, circulating soluble TREM2 positively correlates with severity of steatohepatitis in patients with MASLD/MASH (32, 35) and the transcriptomic profiles of hepatic macrophages in TREM2+ spots reveal an enrichment of genes related to inflammation and extracellular matrix remodeling (32).