ICOSLG and metabolic dysfunction-associated steatohepatitis: In line with ICOSL upregulation in rodent MASH, we observed that sICOSL was significantly higher in MASLD/MASH patients as compared to healthy individuals (2.03 ± 1.09 ng/mL vs 1.29 ± 0.57 ng/mL; p<0.0001; Figure 2A).