Non-classical monocytes in the peripheral blood of PC patients had clear upregulated expression of inflammatory genes (TNF, IL1B, DUSP2, and S100A8), chemokines (CCL3, CCL3L1, CCL4L2, and CXCL8), and TFs (EGR1, FOS, JUN, and JUND) compared with HCs (Figure 5D). The gene discussed is S100A8; the disease is pachyonychia congenita.