Similarly, sHLH is associated with a proportion of CD4dim CD8+ T cells (that are highly activated and cytolytic CD8+ mature T cells) above 1.45% that reliably discriminate sHLH from other causes of systemic inflammation such as flare of systemic juvenile idiopathic arthritis (sJIA) (9). This evidence concerns the gene CD8A and systemic-onset juvenile idiopathic arthritis.