In summary, although some of the mechanistic detail remains to be elucidated, for example, with respect to the role of targeting individual cytokines like IFNγ, overall this study clearly shows that both the parasitic worm product ES-62 and its drug-like SMAs, can protect against lung pathology and inflammation during obesity-accelerated ageing in mice. This evidence concerns the gene IFNG and obesity due to melanocortin 4 receptor deficiency.