IFIH1 and Smith-Magenis syndrome: This particularity makes the IFIH1 gene together with RLRs responsible for the development of the Singleton-Merten syndrome (SMS) (4, 5), an autosomal dominant disease that is manifested by abnormalities in the correct development of the skeleton and vascular system, the appearance of calcifications in the aorta and mitral valve, muscle weakness, psoriasis, and recurrent infections (6–8).