IDH1 and neoplasm: Similarly, deconvolution appeared to be more informative compared to the classification of individual regions according to Garofano subtyping.31 Further investigation of the tumor states within each region revealed spatial heterogeneity with significant increases in intratumoral heterogeneity in the IDH-wt samples compared to IDH1-mutant in the mesenchymal (variance test, P < .001) and progenitor (variance test, P < .001) tumor cell populations (Figure 1E).