Moreover, for the SCD study, multiple gene-metabolite pairs annotated with an SRD lower or equal to 8 (Table 2) had already been reported in the literature, such as the DGKH and tetradecanoyl-CoA (SRD = 8) or UGT2B17 and sn-glycerol 3-phosphate (SRD = 6). Here, DGKH is linked to Schnyder corneal dystrophy.