However, recent studies demonstrate that moderate alcohol consumption may be protective against dementia and cognitive decline.<h4>Methods</h4>We examined astrocyte function, low-density lipoprotein (LDL) receptor-related protein 1 (LRP1), and the NF-κB p65 and IKK-α/β signaling pathways in modulating neuroinflammation and amyloid beta (Aβ) deposition. This evidence concerns the gene NFKB1 and Mental deterioration.