TAMs regulate several early cancer metastasis processes, including invasion, angiogenesis and intravasation by secreting various inflammatory cytokines such as Interleukin 6 (IL-6) and Interleukin 8 (IL-8), as well as angiogenesis factors such as vascular endothelial growth factor (VEGF)4. This evidence concerns the gene CXCL8 and cancer.