To investigate the impact of different TC types on CCL2 and CCL7 secretion specifically by MØs, we conducted experiments using M0 MØs from multiple healthy donors treated with tumor cell-conditioned media (TCM) derived from MDA-MB-231, MDA-MB-468, A-549, H2009, and A-427, with or without various CSF-1R-targeting molecules, including BLZ945, CSF-1R Ab, and CSF1R/CCR2/TGF-β Ab for the MDA-MB-231 cohort (Fig. 2Aiii). The gene discussed is CCR2; the disease is neoplasm.