Moreover, a recent study reports that RRAD expression is increased at the border zone following myocardial infarction in human hearts 37 while other studies reported that RRAD protein levels fall in patients with end-stage non-ischemic heart failure (heart failure with reduced ejection fraction, HFrEF) 33, and in a mouse model of cardiac hypertrophy 36. The gene discussed is RRAD; the disease is heart failure.