MTHFR and peripheral arterial disease: This variant consists of a C (cytosine) to T (thymine) transition at nucleotide 677 in exon 4.18 HHcy and the MTHFR 677 C>T genetic variant emerged as an independent risk factor for subclinical atherosclerosis, implying genetic influences may be potential contributors to the increased burden of atherosclerotic disease that characterizes PAD.