MTHFR and peripheral arterial disease: However, the aim of the present study was to assess whether there is an association between the MTHFR 677 C>T variant and Hcy in the subset of PAD patients and, even after adjusting for the variables possibly associated with the disease that we recorded for this group of patients and which could confound the results, Hcy values remained higher among patients with the minor T allele, regardless of the genetic model evaluated in the statistical analysis, whether the recessive model (TT versus CC+CT) or the dominant model (CT+TT versus CC).