According to several studies, Aβ plaque development occurs in female 3xTg-AD mice from 12 to 18 months, with males showing significantly less Aβ and hyperphosphorylated tau deposition at 18 months (Carroll and Pike, 2008; Creighton et al., 2019; Javonillo et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.