This is important to highlight when considering treatment with SSRIs for AD, as 5-HT1A receptors are critical to hippocampal signaling, activation of growth factor-regulated signaling pathways, and neuronal myelination processes (Gray et al., 2013; Kroeze et al., 2015; Albert and Vahid-Ansari, 2019). The gene discussed is HTR1A; the disease is Alzheimer disease.