PSEN1 and Alzheimer disease: Specifically, several studies in AD mouse models (APP/PS1, Aβ-injected C57BL/6 mice) report efficacy of SSRIs (e.g., fluoxetine) in restoring cognition and cell density in the hippocampus (Cirrito et al., 2011; Ma et al., 2017; Caruso et al., 2021).