Generally, 3xTg mice aged 3–4 months do not exhibit differing corticosterone (CORT) levels compared to controls; however, some 3xTg males did exhibit increased GR mRNA expression in the hippocampus and paraventricular nucleus, suggesting a possible progression toward increased CORT in this AD model (Hebda-Bauer et al., 2013; Nguyen et al., 2020). The gene discussed is NR3C1; the disease is Alzheimer disease.