Although neurobiological changes reported in the 3xTg-AD mouse model remain consistent with development of Aβ plaques (6 months/18 months) and tau/tangles (12 months/18 months; see Figures 1 and 3), behavioral results are more inconsistent (Oddo et al., 2003; Zhang C. et al., 2016). Here, MAPT is linked to Alzheimer disease.