MAPT and Alzheimer disease: Regardless of species, there are five genes commonly targeted in AD Tg models: amyloid-precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2), microtubule-associated protein tau (MAPT), and apolipoprotein E (APOE; Remy et al., 2014; Alzheimer’s Association, 2023).