One such protein termed a ‘seno-antigen’, glycoprotein nonmetastatic melanoma protein B (GPNMB), was formulated into a senolytic vaccine and injected into progeroid mice, effectively reducing SC burden, alleviating pathological effects of obesity and atherosclerosis, and extending lifespan (Suda et al., 2021). Here, GPNMB is linked to obesity due to melanocortin 4 receptor deficiency.