Similarly, the irradiated brain tissue of cancer patients exhibits a significantly higher burden of p16Ink4a-positive senescent astrocytes than age-matched controls and patients with the same cancer type who did not receive radiation (Greene-Schloesser et al., 2012; Turnquist et al., 2019), although whether the irradiated cancer group demonstrated a greater burden of neurocognitive deficits was not determined. The gene discussed is CDKN2A; the disease is cancer.