IFNG and Mental deterioration: In the CSF, levels of several cytokines (e.g., IL-1β, IL-4, IL-6, IL-8, IFNγ, G-CSF, and GM-CSF) are negatively associated with AD-related progression of cognitive decline, suggesting a protective function of these factors (Taipa et al., 2019; Albrecht et al., 2021).