- Cells expressing Nectin-2 need more HSV particles than Nectin-1 for infection (Lopez et al., 2000).- Nectin-1 or -2 can mediate HSV-2 entry, but wide-type HSV-1 can interact with nectin-1 only (Krummenacher et al., 2004).- The amino acid sequence of Nectin-1 is 30% different from Nectin-2. This evidence concerns the gene NECTIN2 and infection.