During the onset of ALI caused by sepsis, the release and activation of multiple pro-inflammatory cytokines such as TNF-α, IL-1, IL-2, IL-6, and IL-8, as well as abnormalities in systemic coagulation function can accelerate the development of the disease and cause a cascade reaction of systemic inflammatory, leading to immune dysfunction and worse lung injury, which is not conducive to patients’ prognosis. This evidence concerns the gene CXCL8 and acute respiratory distress syndrome.