In terms of CKD, the upregulation of the RAAS (especially intrarenally) commonly seen with this disease may lead to the conclusion that Black individuals with CKD, whose renin levels are bolstered, become good candidates for drugs that inhibit the RAAS, including ACE inhibitors.12,* Indeed, JNC 8 recommends ACE inhibitors for all patients with CKD, regardless of race. Here, REN is linked to chronic kidney disease.