The authors of ALLHAT acknowledged the potential faults of their design which “led to a somewhat artificial regimen ... of step-up drugs in the ACE inhibitor group,” and “may have contributed to higher BPs in the ACE inhibitor group, especially in the Black subgroup.”18,† BP differences can hugely impact risk of stroke as well as other outcomes related to morbidity and mortality.19 For stroke (in terms of lisinopril vs. chlorthalidone), the reported RR was 1.40 (95% confidence interval [CI], 1.17–1.68) for Black folks and 1.00 (95% CI, 0.85–1.17) for nonblack folks.17 Here, ACE is linked to Stroke.