A recent study has found that high glucose and high fat-induced ferroptosis in osteoblasts may be the main cause of osteoporosis in DM by activating the methyltransferase-like 3 (METTL3)/Apoptosis signal-regulating kinase 1 (ASK1)-p38 signaling pathway [62]. The gene discussed is METTL3; the disease is diabetes mellitus.