NPPB and obesity due to melanocortin 4 receptor deficiency: After adjustment for age, gender, diabetes mellitus, smoking, obesity, hypertension, arrhythmia, previous CHF, admission SBP ≤90 mmHg, admission creatinine, admission urea, admission sodium and admission NT-proBNP, the association between loop diuretic dosage and the primary end point disappeared (Table 2).