Patients receiving higher doses of loop diuretics more often had diabetes mellitus, previous heart failure, arrhythmias, primary cause of admission was more often fluid overload, had more prior history of CABG, experienced more weight gain, and had more signs of right ventricular fluid overload, higher BMI and lower blood pressure and heart rate, higher admission s-Cr, urea and NT-proBNP. The gene discussed is NPPB; the disease is diabetes mellitus.