After adjustment for age, male sex, obesity, diabetes mellitus, smoking, hypertension, arrhythmia, CHF, admission SBP ≤90 mmHg, admission creatinine, admission urea, admission sodium and admission NT-proBNP, no statistically significant association was found between loop diuretic dosage and one-year CV mortality (Table 2). Here, NPPB is linked to obesity due to melanocortin 4 receptor deficiency.