USP24 regulated and stabilized the protein levels of NCOA4 thereby promoting ferritinophagy during HCMV infection, while the binding of USP24 to pUL38 was able to reduce ferritinophagy to promote iron-dependent ER stress-induced cell death (Santana-Codina and Mancias, 2018; Sun et al., 2018). This evidence concerns the gene USP24 and cytomegalovirus infection.