Instead, CCL2 is essential in regulating the CNS’srepair processes and cellular interactions.40 It also plays a role in Aβ degradation and clearance of neuronaldamage.41 Multiple data obtained as a resultof studies show that significant increases in MCP-1 predict AD, andthis chemokine plays a critical role in the disease process.40 Various clinical data have demonstrated thatMCP-1 levels increase in both CSF and serum of AD patients.42 MCP-1 is also closely associated with the pathogenesisof PD. The gene discussed is CCL2; the disease is Alzheimer disease.