α-Synucleinopathy describes neurodegenerative diseasescharacterizedby abnormal accumulation of α-synuclein protein insoluble inneuronal or glial cells.5,6 These diseases includePD, DLB, and multisystem atrophy.7 α-Synucleinis a 14 kDa cytosolic protein located predominantly at the presynapticterminals of neurons in the hippocampus, striatum, thalamus, cerebellum,and neocortex.6 The α-synuclein mayform many conformations containing amyloidogenic oligomers.8 Mutation and an increase in the concentrationof α-synuclein lead to misfolding of the protein. The gene discussed is SNCA; the disease is Lewy body dementia.