SNCA and Parkinson disease: These misfoldedα-synuclein aggregates stimulate glial cells and other immune-inflammatorycells, inducing neurodegeneration in the substantia nigra, releasinginflammatory cytokines and chemokines.9 PD is the second most common neurodegenerative disease characterizedby the loss of dopaminergic neurons in the substantia nigra and theformation of α-synuclein-containing inclusions in neuronal somaand neurites called Lewy-associated α-synuclein pathologies(LRPs).10,11 Lewy body pathology is observed in approximatelyhalf of the patients with AD.