CSF2 plays a rolein disease prevention in animal models of AD and is currently beingapproved in clinical trials because of its potential to reduce dementia.CSF2 protects neurons in MP models, including MPTP, 6-OHDA, and paraquat,by reducing neuronal apoptosis, Bcl-2, and Bax-related proteins andstimulating brain-derived neurotrophic factors.46 This evidence concerns the gene BDNF and dementia.