These results suggest that the serum proteins CCL14 is a protective factor for colorectal cancer, CXCL14 is a risk factor for colon cancer, CCL14, CCL28 and CXCL12 are protective factors for malignant neoplasm of small intestine, while CCL22 is a risk factor for malignant neoplasm of small intestine. This evidence concerns the gene CCL14 and colonic neoplasm.