These results suggest that the serum proteins CCL14 is a protective factor for colorectal cancer, CXCL14 is a risk factor for colon cancer, CCL14, CCL28 and CXCL12 are protective factors for malignant neoplasm of small intestine, while CCL22 is a risk factor for malignant neoplasm of small intestine. The gene discussed is CCL14; the disease is colorectal cancer.