The results of MR analysis showed that significant causal association between CCL14 [OR (95%CI), 1.083 (1.010–1.161), p = 0.03] and colorectal cancer (finn-b-C3_COLORECTAL), CXCL14 [OR (95%CI), 1.397 (1.150–1.698), p = 7.98E-04] and colon cancer (finn-b-C3_COLON), CCL22 [OR (95%CI), 2.051 (1.350–3.116), p = 7.58E-04], CCL28 [OR (95%CI), 0.741 (0.562–0.977), p = 0.03], CCL14 [OR (95%CI), 0.766 (0.607–0.967), p = 0.03] and CXCL12 [OR (95%CI), 0.576 (0.351–0.946), p = 0.03] and small intestinal malignant neoplasm (finn-b-C3_SMALL_INTESTINE) (Figure 2). This evidence concerns the gene CXCL12 and colorectal cancer.