In vivo study have demonstrated the coupling of glutamate metabotropic receptor 1/5 and GluD1 is essential to the firing of dopamine neurons in the midbrain (Benamer et al., 2018) that are correlated with the physiopathology of schizophrenia (Paladini and Roeper, 2014; Stopper and Floresco, 2015). This evidence concerns the gene GRM1 and schizophrenia.