For the immunohistochemistry, the results are subsequently defined as a score ranging from 0+ (no or fewer than 10% of cells staining); 1+ (faint/barely perceptible membrane staining detected in >10% of the tumor cells); 2+ (HER2 is not uniform/low in intensity, but with circumferential distribution in at least 10% of cells, which makes it slightly equivocal, thus FISH is necessary to confirm its status); and 3+ (strong complete membrane staining of >10% of tumor cells) [11, 12]. The gene discussed is ERBB2; the disease is neoplasm.