The 3 polymorphic alleles of ApoE, ε2, ε3, and ε4, exhibit differential effects on LOAD risks in an isoform-specific manner (Munoz et al., 2019): ApoE3 is the most common allele in the population; ApoE4 variant is found in more than 65% of AD (Heffernan et al., 2016) with 12 folds increase in occurrence of AD (Kim et al., 2014; Liao et al., 2017); whereas ApoE2 is under-represented in AD patients and thought to be neuroprotective (Dorey et al., 2017). This evidence concerns the gene APOE and Alzheimer disease.