IL6 and Anxiety: Other behaviors which could impact on the expression of cognitive performance, e.g., exploration, anxiety, have not been assessed in GFAP-IL6 mice, although a recent study indicates 4 month old GFAP-IL6 homozygous mice exhibit greater depressive-like behavior in the forced swim test, decreased digging behavior and decreased exploratory behavior in the light/dark test compared to wildtype-like (WT) controls (Roberts et al., 2019).