PECAM1 and neoplasm: The transplantation of these CCM/SIL/Ce6 to the MCF-7 tumor-bearing mice for 14 days down-regulated the expression of CD31 and vascular endothelial-cadherin, and significantly reduced the tumor volume compared to the other groups (SIL/Ce6, Ce6) (tumor volume 52 ± 9 mm3 versus 400 mm3) [122].