Momordica charantia polysaccharides dose-dependently attenuated apoptotic cell death in neural cells under oxygen glucose deprivation condition in vitro and reduced infarction volume in ischemic brains in vivo; inhibited lipid peroxidation, and inhibited the JNK3 signaling cascades during cerebral ischemia/reperfusion injury. Here, MAPK10 is linked to brain ischemia.