Fructus corni polysaccharide decreased the alteration in ΔΨm, cytochrome C leakage, and the activation of cleaved caspase-3 by reducing the activation of hippocampus ROS and the MAPK cascade pathway following epilepsy, thereby alleviating the apoptosis of neurons and having a neuroprotective effect on epilepsy. This evidence concerns the gene CASP3 and epilepsy.