DRAIC and cancer: In addition, given that siRNA strategies are not effective in knocking down nuclear RNAs because RNAi-machinery is localized in the cytoplasm [40,41], we need to knockout DRAIC using CRISPR/Cas9 in VMRC-LCD and other cell lines to fully analyze the functions of nuclear DRAIC. Nevertheless, our gene expression analysis presented here suggests the potential involvement of DRAIC in NE-differentiation and cancer-related phenotypes.