In the germline setting, AIP variants and X-chromosome microduplications involving GPR101 are strongly associated with somatotrophinomas, whilst variants in MEN1, PRKAR1A and the SDHx genes (SDHA, SDHB, SDHC, SDHD, SDHAF2) are associated with all pituitary adenoma subtypes but with a predilection for lactotroph hyperplasia/adenomas. Here, AIP is linked to pituitary gland adenoma.