The results of the SHBG analysis showed that SHBG also no longer had a causal relationship with the risk of ovarian cancer and endometriosis (P > 0.05), while high-level SHBG could reduce the risk of endometrial cancer (OR = 0.823, P < 0.001) and its endometrioid histological subtype (OR = 0.822, P < 0.001) but no longer had a causal relationship with non-endometrioid endometrial cancer (OR = 0.811, P = 0.084). Here, SHBG is linked to ovarian carcinoma.