For endometrial cancer, high levels of DHEAS remained a risk factor for endometrial cancer (OR= 1.788, P < 0.001) and its endometrioid histological subtype (OR = 1.700, P = 0.001), but there was no causal relationship between DHEAS and non-endometrioid endometrial cancer (OR = 0.871, P = 0.720). This evidence concerns the gene SULT2A1 and endometrial cancer.