The results showed that SNP sites such as AKR1C2 (rs116900756), AKR1D1 (rs9642092), CYP11B1 (rs1134095), CYP3A7 (rs45446698) appeared simultaneously in the MR analysis results of TT and BioT on ovarian cancer, endometrial cancer, endometriosis, PCOS and POF. This evidence concerns the gene AKR1D1 and polycystic ovary syndrome.