evaluated 107 T2DM patients with an average age of 49.27 ± 4.26 years and showed an increasing trend for the serum VEGF levels between the normal urinary protein, microproteinuria, and the massive proteinuria groups; moreover, changes in the serum VEGF levels were positively associated with the progression of DN (r = 0.518, P < 0.001) (12). This evidence concerns the gene VEGFA and type 2 diabetes mellitus.