After adjusting for relevant variables (age, current smoking, BMI, current drinking, T2DM duration, insurance type, SBP, ACTH, and HbA1c) in model 3, the risk of dyslipidemia was reduced with increasing serum DHEA levels (OR, 0.39, tertile 3 vs. tertile 1; 95% CI, 0.24–0.64, P < 0.001 for trend). This evidence concerns the gene POMC and metabolic syndrome.