INS and Insulin resistance: The analysis focused on indicators of T2D onset and impairment of glycemic homeostasis, including glycated hemoglobin A1c (HbA1c), fasting glucose, fasting insulin, 2-hour postprandial glucose, fasting insulin precursors, the surrogate estimates of insulin resistance (HOMA-IR) and β-cell function (HOMA-B) derived from fasting variables by homeostasis model assessment.