The signal pathway of glycolipid metabolism involved by JNK-1 is very complex, including cross-regulation, and feedback mechanisms of multiple signalings contain AMPK signaling, NF-kB signaling, ROS signaling, and others, affecting the level of glucose and lipid metabolism [30], which is of great significance for the study of metabolic diseases. This evidence concerns the gene NFKB1 and Other metabolic disease.