Furthermore, Yang, S.et al. [67] utilize various single-cell multi-omics techniques, including single-cell transcriptomic sequencing and multiplex fluorescent immunohistochemistry, to comprehensively map the multi-omics landscape of liver metastasis (LM), thereby unraveling prospective mechanisms underlying aggressive inter-metastatic subtypes and validating the regulatory functions of SLC2A1 in remodeling the tumor microenvironment in primary tumors as well as LM lesions (Table 1). Here, SLC2A1 is linked to lymphangioma.