In this manner, non-apoptotic FAS signaling has been shown to prevent lymphoproliferation and autoimmunity, and promote proliferation and “precocious differentiation” of naïve T cells, with implications for adoptive T cell therapies (Alderson et al., 1993; Cruz et al., 2016; Klebanoff et al., 2016). Here, FAS is linked to Autoimmunity.