Yet there are also favourable findings for GnRH-a,in a retrospective cohort study of 550 early miscarriage patients was conducted in 2022, higher aneuploidy rate in early aborted tissues(48.51% vs. 64.19%) and blastocysts(39.69% vs. 52.27%) were found in GnRH-ant protocol than in GnRH-a protocol. This evidence concerns the gene GNRH1 and Miscarriage.